Gerd Pluschke Selected Research

mycolactone

1/2022	Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions.
1/2022	Overview: Mycolactone , the Macrolide Toxin of Mycobacterium ulcerans.
1/2022	Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity.
1/2021	An Antigen Capture Assay for the Detection of Mycolactone, the Polyketide Toxin of Mycobacterium ulcerans.
1/2020	Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans.
11/2017	Infiltrating leukocytes surround early Buruli ulcer lesions, but are unable to reach the mycolactone producing mycobacteria.
1/2017	The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR.
1/2017	Susceptibility to Mycobacterium ulcerans Disease (Buruli ulcer) Is Associated with IFNG and iNOS Gene Polymorphisms.
4/2016	Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model.
2/2016	Interferon-γ Is a Crucial Activator of Early Host Immune Defense against Mycobacterium ulcerans Infection in Mice.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Gerd Pluschke Research Topics

Disease

40	Buruli Ulcer 01/2022 - 01/2006
24	Infections 01/2022 - 03/2004
23	Malaria 01/2022 - 05/2002
13	Human Influenza (Influenza) 01/2020 - 08/2003
7	Necrosis 01/2022 - 08/2011
7	Wounds and Injuries (Trauma) 01/2022 - 09/2011
5	Tuberculosis (Tuberculoses) 01/2022 - 12/2006
5	Skin Diseases (Skin Disease) 01/2020 - 01/2013
5	Ulcer 01/2017 - 01/2006
3	Meningitis 10/2014 - 11/2013
3	Meningococcal Meningitis 05/2014 - 11/2013
3	Anthrax 07/2011 - 10/2006
3	Falciparum Malaria (Plasmodium falciparum Malaria) 05/2005 - 05/2002
2	Coinfection 01/2022 - 01/2006
2	Neglected Diseases 01/2022 - 06/2012
2	Ischemia 01/2022 - 07/2015
2	Meningococcal Infections 05/2014 - 03/2013
2	Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis) 01/2013 - 07/2005
1	Hyperthermia 01/2019
1	Neoplasms (Cancer) 01/2019
1	Hepatocellular Carcinoma (Hepatoma) 09/2018
1	Liver Cirrhosis (Hepatic Cirrhosis) 09/2018
1	Dengue (Dengue Fever) 01/2018
1	Skin Ulcer 01/2017

Drug/Important Bio-Agent (IBA)

24	VaccinesIBA 01/2022 - 05/2002
16	AntigensIBA 01/2020 - 08/2003
15	VirosomesIBA 01/2022 - 08/2003
14	mycolactoneIBA 01/2022 - 09/2009
11	Subunit VaccinesIBA 03/2016 - 12/2002
11	Peptides (Polypeptides)IBA 12/2011 - 08/2003
10	Malaria VaccinesIBA 01/2022 - 01/2006
10	AntibodiesIBA 01/2020 - 01/2006
8	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 07/2005
8	ExotoxinsIBA 01/2022 - 01/2013
6	Rifampin (Rifampicin)FDA LinkGeneric 01/2022 - 10/2007
6	MacrolidesIBA 01/2020 - 01/2013
6	Proteins (Proteins, Gene)FDA Link 02/2015 - 12/2006
5	AcidsIBA 01/2022 - 08/2011
5	Polysaccharides (Glycans)IBA 01/2021 - 04/2008
5	Protein Subunit VaccinesIBA 01/2011 - 05/2002
4	DNA (Deoxyribonucleic Acid)IBA 12/2017 - 01/2006
4	Streptomycin (Streptomycin Sulfate)FDA Link 04/2014 - 10/2007
3	Pharmaceutical PreparationsIBA 01/2022 - 01/2016
3	Cytotoxins (Cytolysins)IBA 01/2021 - 09/2009
3	Capsules (Microcapsules)IBA 10/2014 - 07/2005
3	PolyketidesIBA 01/2013 - 03/2007
3	OligosaccharidesIBA 07/2011 - 04/2006
3	phosphatidylethanolamineIBA 12/2009 - 08/2003
2	FibrinIBA 01/2022 - 07/2015
2	Clarithromycin (Biaxin)FDA LinkGeneric 01/2022 - 01/2011
2	Immunoglobulin G (IgG)IBA 01/2020 - 11/2010
2	Matrix Metalloproteinases (MMPs)IBA 01/2017 - 01/2013
2	InterferonsIBA 02/2016 - 05/2015
2	Recombinant ProteinsIBA 02/2016 - 12/2011
2	Membrane Proteins (Integral Membrane Proteins)IBA 02/2016 - 01/2014
2	4,6- dideoxy- 4- (3- hydroxy- 3- methylbutanamido)- 2- O- methylglucopyranoseIBA 07/2011 - 09/2010
2	Monoclonal AntibodiesIBA 07/2011 - 09/2010
2	PeptidomimeticsIBA 01/2011 - 12/2009
2	CarbohydratesIBA 06/2010 - 10/2006
2	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 06/2010 - 04/2008
1	Carrier Proteins (Binding Protein)IBA 01/2022
1	bafilomycin A1IBA 01/2022
1	phosphatidylinositol 3-phosphateIBA 01/2022
1	AntioxidantsIBA 01/2022
1	Blood Proteins (Serum Proteins)IBA 01/2022
1	CalciumIBA 01/2022
1	paraform (paraformaldehyde)IBA 01/2022
1	Chloroquine (Aralen)FDA LinkGeneric 01/2022
1	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 01/2022
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2022
1	Phosphates (Orthophosphate)IBA 01/2022
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2022
1	Phosphotransferases (Kinase)IBA 01/2022
1	Thromboplastin (Tissue Factor)IBA 01/2022
1	UbiquitinIBA 01/2022
1	Prokaryotic Initiation Factor-2IBA 01/2022
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2022
1	Green Fluorescent ProteinsIBA 01/2022
1	Activating Transcription Factor 4IBA 01/2022
1	Keratins (Keratin)IBA 01/2021
1	phosphorylethanolamine (phosphoethanolamine)IBA 01/2020
1	Virulence Factors (Pathogenicity Factors)IBA 01/2020
1	telacebecIBA 01/2020
1	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 12/2018
1	Hepatitis B Surface Antigens (HBsAg)FDA Link 09/2018
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2017
1	Peptide Hydrolases (Proteases)FDA Link 01/2017
1	GelatinasesIBA 01/2017
1	Toll-Like Receptor 4IBA 02/2016
1	EmulsionsIBA 02/2016
1	LipidsIBA 02/2016
1	AerosolsIBA 10/2015
1	Biological Warfare AgentsIBA 10/2015
1	avermectinIBA 08/2015

Therapy/Procedure

7	Therapeutics 01/2022 - 08/2011
5	Drug Therapy (Chemotherapy) 01/2013 - 01/2011
2	Induced Hyperthermia (Thermotherapy) 01/2019 - 01/2009
2	Combination Drug Therapy (Combination Chemotherapy) 04/2014 - 02/2012
1	Skin Transplantation (Skin Grafting) 01/2017